Answer: Einstein
A case for Sherlock Holmes - 'Elementary, my dear Watson.' This is a clue to the elementary nature of this question. The four scientists named are Ernest Lawrence, Alfred Nobel, Dmitri Mendeleyev and Enrico Fermi, and all will be long remembered, because they each have an element named after them (the last 5 elements in the actinide series). Lawrencium is atomic number 103, nobelium is no.102, mendelevium is no.101, fermium is no.100, and einsteinium is no.99, so the fifth man is Einstein. These five men are all unrelated, and worked in different sciences at different times, but are all closely associated, as the elements named after them are adjacent in the Periodic Table, which can be found in most encyclopaedias. A further clue was the word 'unrelated', a reference to Einstein's Theory of Relativity.